MARK3
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Official Full Name
MAP/microtubule affinity-regulating kinase 3 -
Overview
Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family ( -
Synonyms
MARK3;MAP/microtubule affinity-regulating kinase 3;CTAK1;KP78;EMK-2;C-TAK1;ELKL motif kinase 2;protein kinase STK10;ser/Thr protein kinase PAR-1;cdc25C-associated protein kinase 1;serine/threonine-protein kinase p78;PAR1A;Par-1a
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- His&GST
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
MARK3 involved in several pathways and played different roles in them. We selected most pathways MARK3 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 signaling | RASGRP4,PEA15A,FRS2B,NRG4,DUSP5,DUSP10,HBEGF,WDR83,DUSP6,PAQR3A |
| Cytokine Signaling in Immune system | IFIT11,TRIM26,DUSP7,DUSP10,FRS2A,TRIM48,TRIM17,DAB2IPB,SPRED2,FCGR1B |
| Developmental Biology | PLXNC1,EPHB4B,SPTB,LGI1B,CTNNA2,TCF12,DAB2IPB,PSPN,SCN4A,CSNK2B |
| ARMS-mediated activation | CSF2RA,KBTBD7,DUSP2,FGF10B,SPNA1,EGF,DUSP4,NRG4,SPRED2,FRS3 |
| Downstream signaling of activated FGFR1 | PHB,WDR83,DUSP9,SPRED3,SPRED2,PEA15,RASGRP4,SPNA1,PAQR3B,PAQR3A |
| DAP12 interactions | TRAT1,IL17RD,CSF2RA,AHCYL1,SPTB,SPRED2,DUSP2,KIR2DS2,FRS2B,AGO1 |
| Axon guidance | CLTA,EPHA1,NFATC4,EPHB4B,SRGAP2,NRG2A,KIF4,ARPC1B,ITGB1,SEMA5B |
| Downstream signal transduction | PEA15,SPTBN2,SPNA1,DUSP2,CRKL,IL17RD,THEM4,JAK1,FRS3,FGF18B |
Protein Function
MARK3 has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MARK3 itself. We selected most functions MARK3 had, and list some proteins which have the same functions with MARK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | MOS,PRKD1,MTOR,PRKCBB,SRPK3,CDC42BPB,HIPK1,DMPK,STK32B,SIK2A |
| protein binding | PRDM4,CD33,SLC25A18,STAC3,NR2C2,RICTOR,THBS4,TIRAP,AHCYL1,TCEB2 |
| ATP binding | SEPHS2,APAF1,ACTC1B,ADCY7,YME1L1,PANK1,NOLC1,RUNX2A,RNASEL,MAPKAPK2 |
Interacting Protein
MARK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARK3.
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