Recombinant Mouse Malt1 Protein, Myc/DDK-tagged

• Cat.No.: Malt1-3911M
• Product Overview: Purified recombinant protein of Mouse mucosa associated lymphoid tissue lymphoma translocation gene 1 (Malt1), full length, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 92.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Malt1 MALT1 paracaspase [ Mus musculus (house mouse) ]
• Official Symbol: Malt1
• Synonyms: MALT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; paracaspase; A630046N12; D430033E09Rik; MGC124469; MGC124470
• Gene ID: 240354
• mRNA Refseq: NM_172833
• Protein Refseq: NP_766421
• UniProt ID: Q2TBA3

Reviews

06/26/2022

From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the MALT1 protein in the format and specifications required for their particular studies.

08/19/2020

the manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.

03/20/2020

the MALT1 protein's exceptional qualities, combined with the manufacturer's comprehensive technical support, make it an ideal choice for researchers seeking reliable experimental materials and reliable assistance in their scientific endeavors.

Q&As

Can MALT1 protein play a role in regulating immune responses in transplant patients?

MALT1 inhibitors are being investigated to prevent graft rejection and reduce the need for immunosuppressive drugs in transplant recipients.

Are there any genetic mutations or polymorphisms related to MALT1 protein that impact patient health?

Some genetic variations in MALT1 may influence susceptibility to certain diseases, including autoimmune conditions.

Are there any clinical applications for MALT1 protein in cancer research?

Yes, MALT1 is implicated in lymphoma and other hematological malignancies, making it a potential therapeutic target.

Can MALT1 protein be targeted for cancer treatment?

Yes, researchers are exploring MALT1 inhibitors as potential cancer therapeutics to block its activity in lymphomas.

How does MALT1 protein contribute to lymphocyte activation and proliferation?

MALT1 is involved in the activation of T and B cells, which are essential for the adaptive immune response.