Recombinant Mouse Lmtk3 Protein, Myc/DDK-tagged

• Cat.No.: Lmtk3-3804M
• Product Overview: Purified recombinant protein of mouse full-length lemur tyrosine kinase 3 (Lmtk3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons.
• Molecular Mass: 150.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Lmtk3 lemur tyrosine kinase 3 [ Mus musculus (house mouse) ]
• Official Symbol: Lmtk3
• Synonyms: LMTK3; lemur tyrosine kinase 3; serine/threonine-protein kinase LMTK3; apoptosis-associated tyrosine kinase 3; aatyk3; BC059845; MGC90743
• Gene ID: 381983
• mRNA Refseq: NM_001005511
• Protein Refseq: NP_001005511
• UniProt ID: Q5XJV6