Recombinant Mouse LGALS4 protein, His-tagged

• Cat.No.: LGALS4-326M
• Product Overview: Recombinant Mouse LGALS4 protein (Met1-Ile326), fused to His tag at N-terminus, was expressed in human 293 cells (HEK293).

Specification

• Description: Galectin-4 (Gal-4), also known as L36LBP (L-36 lactose-binding protein). The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-4 expression is concentrated within microvilli in the gastrointestinal epithelium, where it can interact with CD3 and bind activated T cells in the lamina propria during intestinal inflammation. LGALS4 is an S-type lectin that is strongly underexpressed in colorectal cancer.
• Source: HEK293
• Species: Mouse
• Tag: His
• Form: Lyophilized from 0.22 um filtered solution in 50 mM HEPES, 150 mM NaCl, pH7.5. Normally sucrose is added as protectant before lyophilization.
• Molecular Mass: The protein has a calculated MW of 38.6 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Protein length: 326
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Purity: >92% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 centigrade to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: LGALS4
• Official Symbol: LGALS4
• Synonyms: LGALS4; lectin, galactose binding, soluble 4; galectin-4; lactose-binding lectin 4; gal-4
• Gene ID: 16855
• mRNA Refseq: NM_010706
• Protein Refseq: NP_034836
• UniProt ID: Q8K419

Reviews

08/18/2022

Its versatility and consistent performance make it an indispensable tool for a wide range of research applications.

11/01/2020

This exceptional clarity allows for accurate quantification and analysis, contributing to the overall success of my research endeavors.

07/28/2017

When used in Western Blotting experiments, the LGALS4 protein consistently generates clear and distinct protein bands.

Q&As

How is LGALS4 involved in cancer progression?

LGALS4 is often overexpressed in certain cancers and is associated with tumor growth, invasion, and metastasis, making it a potential biomarker for cancer diagnosis and prognosis.

Can LGALS4 be targeted for therapeutic intervention in autoimmune diseases?

Studies suggest that modulating LGALS4 expression or activity may have therapeutic potential in managing autoimmune diseases by regulating immune responses.

Is LGALS4 involved in neurodegenerative disorders?

Emerging research indicates that LGALS4 may play a role in neurodegenerative disorders, making it a target for further investigation in conditions like Alzheimer's disease.

How does LGALS4 contribute to inflammation and immune responses?

LGALS4 is involved in modulating immune responses and inflammation, suggesting its potential as a therapeutic target for inflammatory diseases.

Can LGALS4 be used as a diagnostic marker for cancer?

Research suggests that elevated levels of LGALS4 may serve as a diagnostic marker for certain cancers, aiding in early detection.