Recombinant Mouse Ldlrad4 Protein, Myc/DDK-tagged

• Cat.No.: Ldlrad4-3768M
• Product Overview: Purified recombinant protein of mouse full-length low density lipoprotein receptor class A domain containing 4 (Ldlrad4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Myc&DDK
• Description: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
• Molecular Mass: 33.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ldlrad4 low density lipoprotein receptor class A domain containing 4 [ Mus musculus (house mouse) ]
• Official Symbol: Ldlrad4
• Synonyms: Ldlrad4; low density lipoprotein receptor class A domain containing 4; C18orf1; A430083H02; D18Ertd653; D18Ertd653e; 8230401C20Rik; A430108L08Rik; D330030L18Rik; low-density lipoprotein receptor class A domain-containing protein 4
• Gene ID: 52662
• mRNA Refseq: NM_172631
• Protein Refseq: NP_766219
• UniProt ID: Q8BWJ4