Recombinant Mouse Kitlg, Fc-tagged

• Cat.No.: Kitlg-486M
• Product Overview: The extracellular domain of mouse SCF (aa 26-214) is fused to the N-terminus of the Fc region of mouse IgG2a.

Specification

• Species: Mouse
• Source: CHO
• Tag: Fc
• Protein Length: 26-214 a.a.
• Description: Stem cell factor (SCF), also known as cKit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28-40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/cKit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Purity: ≥98% (SDS-PAGE)
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Kitl?kit ligand [?Mus musculus?(house mouse) ]
• Official Symbol: Kitlg
• Synonyms: Kitl; Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted; kit ligand; cloud gray; C-kit ligand; Steel factor; grizzle-belly; stem cell factor; mast cell growth factor; hematopoietic growth factor KL
• Gene ID: 17311
• mRNA Refseq: NM_013598
• Protein Refseq: ?NP_038626
• UniProt ID: P20826
• Chromosome Location: 10 D1; 10 51.4 cM
• Pathway: Adaptive Immune System; Constitutive PI3K/AKT Signaling in Cancer; Cytokine-cytokine receptor interaction
• Function: cytokine activity; growth factor activity; protein binding