Recombinant Mouse Irf5 Protein, Myc/DDK-tagged

• Cat.No.: Irf5-3576M
• Product Overview: Purified recombinant protein of mouse full-length interferon regulatory factor 5 (Irf5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway.
• Molecular Mass: 56.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Irf5 interferon regulatory factor 5 [ Mus musculus (house mouse) ]
• Official Symbol: Irf5
• Synonyms: IRF5; interferon regulatory factor 5; IRF-5; interferon regulatory factor 5 bone marrow; mirf5; AW491843
• Gene ID: 27056
• mRNA Refseq: NM_012057
• Protein Refseq: NP_036187
• UniProt ID: P56477