IRF5
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Official Full Name
interferon regulatory factor 5 -
Overview
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. -
Synonyms
IRF5;interferon regulatory factor 5;SLEB10;IRF-5;OTTHUMP00000212904;OTTHUMP00000212905;OTTHUMP00000212907;OTTHUMP00000212910
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
- GST
- Flag
- His&SUMO
Involved Pathway
IRF5 involved in several pathways and played different roles in them. We selected most pathways IRF5 participated on our site, such as Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Toll-like receptor signaling pathway | FOS,IL12B,TRAF6,IFNAR2,RIPK1,TLR1,RAC1,TLR5,RAC1B,AKT3A |
Protein Function
IRF5 has several biochemical functions, for example, protein binding,regulatory region DNA binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF5 itself. We selected most functions IRF5 had, and list some proteins which have the same functions with IRF5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ELK1,SIM1A,TA,POU3F1,HOXC6A,HOXB2,TADA2A,TFDP1,NFIA,ZFP11 |
| regulatory region DNA binding | IRF6,IRF8,IRF4A,IRF2A,IRF1B,HMGA2,NFKB1,IRF3,IRF1A |
| protein binding | NR2C1,STAT5A,CCDC151,APC,AP1M1,CAPNS1,ITGA6,MBD3,CMKLR1,REXO1L1 |
Interacting Protein
IRF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF5.
SGTA;RELA;MAVS;tnfa_human_isre1_dna-probe;TNF;GTPBP1;IRF6;PPM1G;CEP152;HIVEP1;RGS3
Resources
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References
- Ren, JY; Chen, X; et al. IKK beta is an IRF5 kinase that instigates inflammation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:17438-17443(2014).
- AlFadhli, S; Jahabani, I; et al. Association of interferon regulatory factor 5 (IRF5) markers with an increased risk of lupus and overlapping autoimmunity in a Kuwaiti population. ANNALS OF HUMAN BIOLOGY 41:531-539(2014).
