Recombinant Mouse interleukin 9 Protein, His&Flag tagged

• Cat.No.: Il9-078M
• Product Overview: Recombinant mouse IL-9 protein (P15247) (Gln 19-Pro 144) with both His, Flag tag at the C-terminus was expressed in HEK293.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Flag&His
• Protein Length: 19-144aa
• Description: Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. Affects intestinal epithelial permeability and adaptive immunity. In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5.
• Tag: C-His&Flag
• Molecular Mass: 16.9 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: Il9 interleukin 9 [ Mus musculus (house mouse) ]
• Official Symbol: Il9
• Synonyms: IL9; interleukin 9; interleukin-9; cytokine P40; T-cell growth factor P40; P40; Il-9
• Gene ID: 16198
• mRNA Refseq: NM_008373
• Protein Refseq: NP_032399
• UniProt ID: P15247