Recombinant Mouse Ing3 Protein, Myc/DDK-tagged

• Cat.No.: Ing3-3537M
• Product Overview: Purified recombinant protein of mouse full-length inhibitor of growth family, member 3 (Ing3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
• Molecular Mass: 45.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ing3 inhibitor of growth family, member 3 [ Mus musculus (house mouse) ]
• Official Symbol: Ing3
• Synonyms: ING3; inhibitor of growth family, member 3; inhibitor of growth protein 3; p47 regulator protein; P47ING3; 1300013A07Rik
• Gene ID: 71777
• mRNA Refseq: NM_023626
• Protein Refseq: NP_076115
• UniProt ID: Q8VEK6