Recombinant Mouse IFNA14, His-tagged

• Cat.No.: IFNA14-224M
• Product Overview: A DNA sequence encoding the mouse IFNA14 (NP_996858.1)(Cys24-Lys189) was expressed with a C-terminal polyhistidine tag.

Specification

• Description: Interferon alpha-14, also known as Interferon alpha-H, IFN-alpha-14, LeIF H, Interferon lambda-2-H and IFNA14, is a secreted protein which belongs to the alpha/beta interferon family. IFNA14 is produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.Interferons (IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, or parasites or tumor cells. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs belong to the large class of glycoproteins known as cytokines. IFNs have other functions: they activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes; and they increase the ability of uninfected host cells to resist new infection by virus. Certain host symptoms, such as aching muscles and fever, are related to the production of IFNs during infection.
• Source: Human Cells
• Species: Mouse
• Tag: His
• Predicted N Terminal: Cys 24
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
• Molecular Mass: The recombinant mouse IFNA14 comprises 177 amino acids and has a predicted molecular mass of 20.5 kDa. The apparent molecular mass of the protein is approximately 20 kDa in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 eu per μg of the protein as determined by the lal
• Purity: >90 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Protein length: 24-189 a.a.

Gene Information

• Gene Name: Ifna14 interferon, alpha 14 [ Mus musculus ]
• Official Symbol: IFNA14
• Synonyms: IFNA14; interferon, alpha 14; RP23-67C1.2; MGC155959; OTTMUSG00000007662
• Gene ID: 404549
• mRNA Refseq: NM_206975
• Protein Refseq: NP_996858
• Pathway: Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Hepatitis C, organism-specific biosystem
• Function: cytokine activity