Recombinant Mouse HAO1, without tag

• Cat.No.: HAO1-839M
• Product Overview: Recombinant Mouse Hydroxyacid oxidase 1 (HAOX1) (a.a.1-370) was expressed in E.coli with no tag.

Specification

• Source: E.coli
• Species: Mouse
• Form: Liquid
• Molecular Mass: Theoretical molecular weight: ~41kDa
• AA Sequence: MLPRLVCISDYEQHVRSVLQKSVYD YYRSGANDQETLADNIQAFSRWKLY PRMLRNVADIDLSTSVLGQRVSMPI CVGATAMQCMAHVDGELATVRACQT MGTGMMLSSWATSSIEEVAEAGPEA LRWMQLYIYKDREISRQIVKRAEKQ GYKAIFVTVDTPYLGNRIDDVRNRF KLPPQLRMKNFETNDLAFSPKGNFG DNSGLAEYVAQAIDPSLSWDDITWL RRLTSLPIVVKGILRGDDAKEAVKH GVDGILVSNHGARQLDGVPATIDVL PEIVEAVEGKVEVFLDGGVRKGTDV LKALALGAKAVFVGRPIIWGLAFQG EKGVQDVLEILKEEFRLAMALSGCQ NVKVIDKTLVRKNPLAVSKI
• Purity: > 95% as determined by SDS-PAGE.
• Storage: Short Term Storage +4°C, Long Term Storage -20°C. Prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
• Concentration: 2.5mg/ml
• Storage Buffer: 20mM Tris-HCl, pH8.0, 200mM NaCl, 10% Glycerol.
• Tag: Non
• Protein length: 1-370

Gene Information

• Gene Name: Hao1 hydroxyacid oxidase 1, liver [ Mus musculus ]
• Official Symbol: HAO1
• Synonyms: HAO1; hydroxyacid oxidase 1, liver; hydroxyacid oxidase 1; HAOX1; glycolate oxidase 1; GOX; Gox1; Hao-1; MGC141211
• Gene ID: 15112
• mRNA Refseq: NM_010403
• Protein Refseq: NP_034533
• Pathway: Glyoxylate and dicarboxylate metabolism, organism-specific biosystem; Glyoxylate and dicarboxylate metabolism, conserved biosystem; Glyoxylate metabolism, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Peroxisome, organism-specific biosystem
• Function: (S)-2-hydroxy-acid oxidase activity; (S)-2-hydroxy-acid oxidase activity; FMN binding; catalytic activity; glycolate oxidase activity; long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity; medium-chain-(S)-2-hydroxy-acid oxidase activity; oxidoreductase activity; very-long-chain-(S)-2-hydroxy-acid oxidase activity

Reviews

05/09/2022

Worked well in experiments.

11/28/2020

Great for academic research.

01/28/2020

Very satisfied, will buy again.

Q&As

How is HAO1 implicated in metabolic disorders?

Dysregulation of HAO1 is linked to metabolic disorders and fatty liver disease.

Are there existing or potential therapeutic strategies targeting HAO1?

Therapeutic approaches may include modulation of HAO1 activity or expression.

How does HAO1 contribute to fatty acid metabolism?

It oxidizes specific fatty acids, contributing to their breakdown.

What are the key biological functions of HAO1?

HAO1 is involved in peroxisomal fatty acid oxidation, crucial for lipid metabolism.

What are the potential consequences of HAO1 overexpression?

HAO1 overexpression may lead to oxidative stress and liver dysfunction.

What role does HAO1 play in liver function?

HAO1 supports liver function by participating in lipid catabolism.

How is HAO1 activity regulated in cells?

Cellular regulation of HAO1 involves transcriptional and post-translational mechanisms.