Recombinant Mouse Gdf15 Protein, Ser189-Ala303, N-hFc tagged, Biotinylated

• Cat.No.: Gdf15-263M
• Product Overview: Recombinant mouse GDF15-N-hFc protein was developed from HEK293 and has a target region of N-hFc.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Fc
• Protein Length: Ser189-Ala303
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation.
• Conjugation/Label: Biotin
• Form: Lyophilised
• Endotoxin: Endotoxin level was found to be less than 0.1 ng/μg (1 EU/μg).
• Notes: FOR RESEARCH USE ONLY (RUO).
• Storage: The lyophilized protein is stable for at least 1 year from date of receipt at -20 centigrade.
• Storage Buffer: Lyophilised from 0.2 μm filtered PBS solution pH 7.4. Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20 sec, 5K RPM

Gene Information

• Gene Name: Gdf15 growth differentiation factor 15 [ Mus musculus ]
• Official Symbol: Gdf15
• Synonyms: GDF15; growth differentiation factor 15; growth/differentiation factor 15; GDF-15; macrophage inhibiting cytokine-1; SBF; MIC-1; NAG-1
• Gene ID: 23886
• mRNA Refseq: NM_011819
• Protein Refseq: NP_035949
• UniProt ID: Q6NX63