Recombinant Mouse Enpp1 protein, Myc/DDK-tagged

• Cat.No.: Enpp1-78M
• Product Overview: Recombinant Mouse Enpp1 protein transcript variant 2, fused to Myc/DDK-tag at C-terminus, was expressed in human 293 cells (HEK293).

Specification

• Description: This gene encodes a member of the nucleoside pyrophosphatase/phosphodiesterase family of enzymes that catalyzes the hydrolysis of pyrophosphate and phosphodiester bonds in nucleotide triphosphates and oligonucleotides, respectively, to generate nucleoside 5'-monophosphates. The encoded protein is a type II transmembrane glycoprotein that negatively regulates bone mineralization. Mice harboring a nonsense mutation in this gene, termed tiptoe walking (ttw), exhibit ectopic ossification of the spinal ligaments. The encoded protein binds to the insulin receptor, inhibits downstream signaling events and induces insulin resistance and glucose tolerance. This gene is located adjacent to a paralog on chromosome 10. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: HEK293
• Species: Mouse
• Tag: Myc&DDK
• Form: 80 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 103.5 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 μg/mL as determined by microplate BCA method

Gene Information

• Gene Name: Enpp1
• Official Symbol: Enpp1
• Synonyms: Pca; ttw; twy; M6S1; NPP1; Npps; PC-1; Ly-41; Pca-1; Pdnp1; C76301; CD203c; E-NPP1; E-NPP 1; AI428932; 4833416E15Rik
• Gene ID: 18605
• mRNA Refseq: NM_008813.4
• Protein Refseq: NP_032839.3
• UniProt ID: P06802