ENPP1
-
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 1 -
Overview
Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) is a single-pass, type II transmembrane protein primarily involved in ATP hydrolysis at the plasma membrane. Targeting of ENPP1 to the basolateral cell surface relies on the presence of a carboxy- -
Synonyms
ENPP1;ectonucleotide pyrophosphatase/phosphodiesterase 1;M6S1, NPPS, PDNP1;ectonucleotide pyrophosphatase/phosphodiesterase family member 1;PC 1;PCA1;E-NPP 1;Ly-41 antigen;alkaline phosphodiesterase 1;plasma-cell membrane glycoprotein 1;plasma-c
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- C-His
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293T
- Yeast
- In Vitro Cell Free System
- Myc&DDK
- His
- His&GST
- Non
- GST
- His&Fc&Avi
Involved Pathway
ENPP1 involved in several pathways and played different roles in them. We selected most pathways ENPP1 participated on our site, such as Purine metabolism,Starch and sucrose metabolism,Nicotinate and nicotinamide metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENPP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | OGDH,MINPP1B,ITPA,Acsm2a,GALNT9,PLD4,ATP6V0E2,CYP2A12,MTHFD2L,CHSY1 |
| Purine metabolism | GUK1B,AMPD1,PDE4C,PAPSS1,PDE3B,NME2,PDE6H,CANT1B,PAPSS2,PDE1A |
| Nicotinate and nicotinamide metabolism | NNT,NT5C1B,AOX4,NT5C3B,NMNAT3,NMRK1,NT5C2A,NMNAT1,NADKD1,PNP |
| Pantothenate and CoA biosynthesis | AASDHPPT,BCAT2,PANK1,PPCDC,UPB1,COASY,DPYD,PPCS,PANK4,PANK3 |
| Starch and sucrose metabolism | UGT1A4,UGT1A6,UGT2A1,UGT1A1,GYS2,AMY2A5,UGT1A6A,G6PC3,GUSB,UGT1A7C |
Protein Function
ENPP1 has several biochemical functions, for example, 3-phosphoadenosine 5-phosphosulfate binding,ATP binding,NADH pyrophosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ENPP1 itself. We selected most functions ENPP1 had, and list some proteins which have the same functions with ENPP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | CNBP,MARCH5L,RNF113A,ALAD,ZDHHC3,DIDO1,MECR,PIAS3,S100A8,PRKCA |
| nucleoside-triphosphate diphosphatase activity | DCTPP1 |
| 3-phosphoadenosine 5-phosphosulfate binding | CHST15,CHST12,GAL3ST4,HS3ST5 |
| protein binding | CEP164,MC2R,PCGF2,LTA4H,METTL13,LAT,BLM,PSAP,LTF,GDI2 |
| scavenger receptor activity | TMPRSS13B,LOXL3A,SUSD2,LOXL4,GM106,SCARA5,HHIPL1,SCARF1,VTNB,LOXL3 |
| nucleic acid binding | ZNF292A,INSM1A,EXD2,ZFY1,HDLBPA,EAR5,FAM90A1,RNASEL4,PRKRIRB,ZNF143A |
| nucleotide diphosphatase activity | ENPP2 |
| phosphodiesterase I activity | ENPP2,FAN1,APEX1 |
| protein homodimerization activity | CEACAM1,TBX15,PEX11B,SUMF1,STUB1,SLK,THRA,KCNH2,HMOX1,MID1 |
Interacting Protein
ENPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ENPP1.
INSR;Dlg4;SQSTM1
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References
- Li, LY; Yin, Q; et al. Hydrolysis of 2 ' 3 '-cGAMP by ENPP1 and design of nonhydrolyzable analogs. NATURE CHEMICAL BIOLOGY 11:235-235(2015).
- Ito, N; Wijenayaka, AR; et al. Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli. MOLECULAR AND CELLULAR ENDOCRINOLOGY 399:208-218(2015).
