Recombinant Mouse Dnajc3 Protein, MYC/DDK-tagged

• Cat.No.: Dnajc3-006M
• Product Overview: Purified recombinant protein of full-length mouse DnaJ heat shock protein family (Hsp40) member C3 (Dnajc3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 57.5 kDa
• Purity: >80%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 [ Mus musculus (house mouse) ]
• Official Symbol: Dnajc3
• Synonyms: Dnajc3; DnaJ heat shock protein family (Hsp40) member C3; p58; mp58; Prkri; p58IPK; Dnajc3a; Dnajc3b; AA408985; AU067833; dnaJ homolog subfamily C member 3; DnaJ (Hsp40) homolog, subfamily C, member 3; DnaJ (Hsp40) homolog, subfamily C, member 3A; DnaJ (Hsp40) homolog, subfamily C, member 3B; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58; protein kinase, interferon inducible double stranded RNA dependent inhibitor
• Gene ID: 100037258
• mRNA Refseq: NM_008929
• Protein Refseq: NP_032955
• UniProt ID: Q91YW3