Recombinant Mouse Dmpk Protein, Myc/DDK-tagged

• Cat.No.: Dmpk-2586M
• Product Overview: Purified recombinant protein of mouse full-length dystrophia myotonica-protein kinase (Dmpk), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeletal and smooth muscle, and a function in cytoskeletal remodeling has been described. Transcripts with expanded CUG repeats in the 3' untranslated region mediate alternative splicing of several genes and sequester RNA binding proteins and RNA transcripts that contain CAG repeats, resulting in myotonic dystrophy, an autosomal dominant neuromuscular disorder. Alternative splicing results in multiple protein coding and non-coding transcript variants.
• Molecular Mass: 70.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dmpk dystrophia myotonica-protein kinase [ Mus musculus (house mouse) ]
• Official Symbol: Dmpk
• Synonyms: DMPK; dystrophia myotonica-protein kinase; myotonin-protein kinase; DM-kinase; dystrophia myotonica kinase, B15; myotonic dystrophy protein kinase; DM; DMK; Dm15; MDPK; MT-PK
• Gene ID: 13400
• mRNA Refseq: NM_032418
• Protein Refseq: NP_115794
• UniProt ID: P54265