Recombinant Mouse Dmap1 Protein, Myc/DDK-tagged

Cat.No. : Dmap1-2582M
Product Overview : Purified recombinant protein of mouse full-length DNA methyltransferase 1-associated protein 1 (Dmap1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Species : Mouse
Source : HEK293
Tag : DDK&Myc
Description : Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
Molecular Mass : 53.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name Dmap1 DNA methyltransferase 1-associated protein 1 [ Mus musculus (house mouse) ]
Official Symbol Dmap1
Synonyms DMAP1; DNA methyltransferase 1-associated protein 1; DNMT1 associated protein-1; DNMT1-associated protein 1; MAT1-mediated transcriptional repressor; DNMAP1; Dmtap1; DNMTAP1; mKIAA1425; 1500016M21Rik
Gene ID 66233
mRNA Refseq NM_023178
Protein Refseq NP_075667
UniProt ID Q9JI44

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