Recombinant Mouse Dlg4 Protein, Myc/DDK-tagged

• Cat.No.: Dlg4-2576M
• Product Overview: Purified recombinant protein of mouse full-length discs large MAGUK scaffold protein 4 (Dlg4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (Probable).
• Molecular Mass: 80.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dlg4 discs large MAGUK scaffold protein 4 [ Mus musculus (house mouse) ]
• Official Symbol: Dlg4
• Synonyms: DLG4; discs, large homolog 4 (Drosophila); disks large homolog 4; SAP-90; PSD-95 beta; PSD-95 alpha 2b; discs large homolog 4; synapse-associated protein 90; postsynaptic density protein 95; Dlgh4; PSD95; SAP90; PSD-95; SAP90A
• Gene ID: 13385
• mRNA Refseq: NM_001109752
• Protein Refseq: NP_001103222
• UniProt ID: Q62108