DLG4
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Official Full Name
Dlg4 discs, large homolog 4 (Drosophila) -
Synonyms
DLG4;discs, large homolog 4 (Drosophila);disks large homolog 4;SAP-90;PSD-95 beta;PSD-95 alpha 2b;discs large homolog 4;synapse-associated protein 90;postsynaptic density protein 95;Dlgh4;PSD95;SAP90;PSD-95;SAP90A
Recombinant Proteins
- Human
- Rat
- Mouse
- HEK293
- Wheat Germ
- Mammalian Cells
- E.coli
- In Vitro Cell Free System
- DDK
- Myc
- GST
- His
- Non
- Avi
- Fc
- Flag
Involved Pathway
DLG4 involved in several pathways and played different roles in them. We selected most pathways DLG4 participated on our site, such as ARMS-mediated activation,Activation of Ca-permeable Kainate Receptor,Activation of Kainate Receptors upon glutamate binding, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of Ca-permeable Kainate Receptor | DLG3,NCALDA,DLG1L |
| ARMS-mediated activation | FGFR1B,CSF2RA,AKAP9,RASGRP1,CSK,SPRED3,CRK,FGF8B,DUSP10,FGF20A |
| CREB phosphorylation through the activation of Ras | SLC14A2,AKAP9,NEFLB,PDPK1A |
| Axon guidance | PEA15,LOC608458,SEMA3E,EFNB3,RND1L,AP2M1,MYL12A,IL17RD,SDCBP,SCN4A |
| Activation of NMDA receptor upon glutamate binding and postsynaptic events | SLC14A2,AKAP9,ADCY3,CAMKK1B,ADCY1,ADCY8,CREB1B,CREB1,PDPK1A,NEFLB |
| CREB phosphorylation through the activation of CaMKII | SLC14A2,NEFLB,AKAP9,CREB1B,NETO2 |
| Cocaine addiction | SLC18A1,GRIN3A,GRIN2A,GRIN3B,GNAI1,RELA,GRIA2,ATF4,BDNF,PDYN |
| Activation of Kainate Receptors upon glutamate binding | DLG1L,DLG3,NCALDA,GNB5 |
Protein Function
DLG4 has several biochemical functions, for example, D1 dopamine receptor binding,P2Y1 nucleotide receptor binding,PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLG4 itself. We selected most functions DLG4 had, and list some proteins which have the same functions with DLG4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | PHB,PFKM,CEP135,TCF4,MAP2K1,PIAS3,NCL,MAPRE1,MED12,PCGF1 |
| PDZ domain binding | GRASP,GJA1,LNX1,ARHGAP29,CXXC4,PSEN1,BAIAP2,LRP2,GRIK2,SSTR2 |
| guanylate kinase activity | GUK1,DLG1L,TJP2,DLG3,DLG1,GUK1A,MPP3,DLG4B,DLG2,MPP2 |
| scaffold protein binding | CHUK,LRP4,PANX1,SRC,SHANK1,NCK2,NLRP1,KRT18,KRT8,KCNQ1 |
| beta-1 adrenergic receptor binding | MAGI2 |
| kinase binding | CHP1,BARD1,SNAI1,TOLLIP,C2orf44,PER1,SRC,RPS3,HAP1,DLG3 |
| ionotropic glutamate receptor binding | DLG4B,DLG3,ADRB2,DLG1,FLOT2,GNAS,RAB4A,SHANK3,DRD2,DLG1L |
| protein binding | CD58,GRM1,NUPL1,PHF23,STX4A,UPF3A,WBP1,IKBKE,RHEB,LTBR |
| protein phosphatase binding | MVP,PPP6R1,IRS2,NEK2,AP3B1,KAT2A,ERBB2,MET,ANAPC4,GRB2 |
Interacting Protein
DLG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLG4.
Kcna4;ERBB4;Dlgap1;KCNA4
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References
- Dorostkar, MM; Burgold, S; et al. Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model. BRAIN 137:3319-3326(2014).
