Recombinant Mouse Dapk2 Protein, Myc/DDK-tagged

• Cat.No.: Dapk2-2452M
• Product Overview: Purified recombinant protein of mouse full-length death-associated protein kinase 2 (Dapk2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytes motility by controlling cell spreading and polarization.
• Molecular Mass: 42.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dapk2 death-associated protein kinase 2 [ Mus musculus (house mouse) ]
• Official Symbol: Dapk2
• Synonyms: DAPK2; death-associated protein kinase 2; DRP-1; DAP kinase 2; death-associated kinase 2; DAP-kinase-related protein 1 beta isoform
• Gene ID: 13143
• mRNA Refseq: NM_010019
• Protein Refseq: NP_034149
• UniProt ID: Q8VDF3