Recombinant Mouse Coro1c Protein, Myc/DDK-tagged

• Cat.No.: Coro1c-2273M
• Product Overview: Purified recombinant protein of mouse full-length coronin, actin binding protein 1C (Coro1c), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Required for normal distribution of mitochondria within cells.
• Molecular Mass: 53.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Coro1c coronin, actin binding protein 1C [ Mus musculus (house mouse) ]
• Official Symbol: Coro1c
• Synonyms: CORO1C; coronin, actin binding protein 1C; coronin-1C; coronin 3; coronin-3; coronin 1c; AL022675; AW455561; AW548837; MGC102522
• Gene ID: 23790
• mRNA Refseq: NM_011779
• Protein Refseq: NP_035909
• UniProt ID: Q9WUM4