Recombinant Mouse Cops6 Protein, Myc/DDK-tagged

• Cat.No.: Cops6-2264M
• Product Overview: Purified recombinant protein of mouse full-length COP9 signalosome subunit 6 (Cops6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN.
• Molecular Mass: 35.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cops6 COP9 signalosome subunit 6 [ Mus musculus (house mouse) ]
• Official Symbol: Cops6
• Synonyms: COPS6; COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana); COP9 signalosome complex subunit 6; SGN6; COP9 complex S6; signalosome subunit 6; JAB1-containing signalosome subunit 6; COP9 (constitutive photomorphogenic), subunit 6; Sgn3; VIP/MOV34
• Gene ID: 26893
• mRNA Refseq: NM_012002
• Protein Refseq: NP_036132
• UniProt ID: O88545