COPS6

  • Official Full Name

    COP9 signalosome subunit 6

  • Overview

    The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]

  • Synonyms

    COPS6;COP9 signalosome subunit 6;CSN6;MOV34-34KD;COP9 signalosome complex subunit 6;SGN6;hVIP;H_NH0506M12.12;MOV34 homolog, 34 kD;signalosome subunit 6;vpr-interacting protein;COP9 subunit 6 (MOV34 homolog, 34 kD);JAB1-containing signalosome subunit 6;COP9 constitutive photomorphogenic homolog subunit 6

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
COPS6-15905H Recombinant Human COPS6, His-tagged E.coli Human His 1-327aa
COPS6-1706H Recombinant Human COPS6 Protein, GST-tagged Wheat Germ Human GST
COPS6-2515Z Recombinant Zebrafish COPS6 Mammalian Cell Zebrafish His
COPS6-3783M Recombinant Mouse COPS6 Protein Mammalian Cell Mouse His
COPS6-7355HCL Recombinant Human COPS6 293 Cell Lysate HEK293 Human Non
COPS6-1890M Recombinant Mouse COPS6 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
COPS6-1890M-B Recombinant Mouse COPS6 Protein Pre-coupled Magnetic Beads HEK293 Mouse
COPS6-1962HF Recombinant Full Length Human COPS6 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 327 amino acids
Cops6-2264M Recombinant Mouse Cops6 Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
COPS6-2784H Recombinant Human COPS6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK

    Involved Pathway

    COPS6 involved in several pathways and played different roles in them. We selected most pathways COPS6 participated on our site, such as DNA Damage Recognition in GG-NER,DNA Repair,Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NOD pathway PRDM1,AAMP,NLRP2,NLRP12,NLRP3,NLRP4,SUGT1,NLRP10,NLRP7
    Nucleotide Excision Repair POLD2,LIG1,INO80C,ERCC4,COPS2,INO80B,BIVM-ERCC5,GTF2H3-2,GTF2H2,RPA2
    DNA Damage Recognition in GG-NER MCRS1,ACTL6A,COPS7A,INO80B,COPS5,INO80E,DDB1,COPS8,INO80,NFRKB
    Transcription-Coupled Nucleotide Excision Repair (TC-NER) COPS3,ZFP830,COPS2,ZNF830,COPS7B,ERCC8,KIAA1530,COPS8,PPIE,COPS7A
    DNA Repair COPS7B,ZNF830,ALKBH2,CLSPN,RAD9,INO80C,EYA4,YY1,RTEL1,GEN1
    Formation of TC-NER Pre-Incision Complex ZNF830,KIAA1530,ERCC8,COPS3,COPS8,GPS1,COPS4,DDB1,TCEA1,PPIE
    Global Genome Nucleotide Excision Repair (GG-NER) MCRS1,PIAS3,ACTL6A,USP45,INO80E,COPS7A,ACTR5,COPS2,PARP2,CHD1L

    Protein Function

    COPS6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS6 itself. We selected most functions COPS6 had, and list some proteins which have the same functions with COPS6. You can find most of the proteins on our site.

    Function Related Protein
    protein binding DARS,ZFP259,FAM49B,CDCA5,Raet1a,NUDT18,ANTXR2,ADAM12,CCL3,SHC1

    Interacting Protein

    COPS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS6.

    COPS3;COPS5;SFN

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