Recombinant Mouse Col2a1 protein, His-tagged

• Cat.No.: Col2a1-36M
• Product Overview: Recombinant Mouse Col2a1 fused with His tag was expressed in HEK293.

Specification

• Description: This gene encodes the alpha-1 subunit of the fibril-forming type II collagen, the major component of cartilage and the vitreous humor of the eye. The encoded preproprotein forms homotrimeric, triple helical procollagen that undergoes proteolytic processing during fibirl formation. Mice harboring certain mutations in this gene exhibit severe chondrodysplasia characterized by short limbs and trunch, craniofacial deformities and cleft palate. A complete lack of the encoded protein in mice results in postnatal lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
• Source: HEK293
• Species: Mouse
• Tag: His
• Form: Tris-based buffer, 50% glycerol
• Purity: >90% (SDS-PAGE)
• Storage: Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade. Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.

Gene Information

• Gene Name: Col2a1 collagen, type II, alpha 1 [ Mus musculus ]
• Official Symbol: Col2a1
• Synonyms: COL2A1; collagen, type II, alpha 1; collagen alpha-1(II) chain; chondrocalcin; alpha-1 type II collagen; disproportionate micromelia; procollagen, type II, alpha 1; Dmm; Col2; Del1; Col2a; Col2a-1; M100856; Rgsc856; MGC90638
• Gene ID: 12824
• mRNA Refseq: NM_001113515
• Protein Refseq: NP_001106987
• UniProt ID: P28481
• Chromosome Location: 15 F1; 15 53.97 cM
• Pathway: Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem
• Function: extracellular matrix structural constituent; platelet-derived growth factor binding