Recombinant Mouse Calcoco2 Protein, Myc/DDK-tagged

• Cat.No.: Calcoco2-1936M
• Product Overview: Purified recombinant protein of mouse full-length calcium binding and coiled-coil domain 2 (Calcoco2), transcript variant 1, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.
• Molecular Mass: 57 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Calcoco2 calcium binding and coiled-coil domain 2 [ Mus musculus (house mouse) ]
• Official Symbol: Calcoco2
• Synonyms: CALCOCO2; calcium binding and coiled-coil domain 2; calcium-binding and coiled-coil domain-containing protein 2; nuclear domain 10 protein NDP52; nuclear domain 10 protein 52 like 1; Ndp52; C77254; Ndp52l1; 2410154J16Rik
• Gene ID: 76815
• mRNA Refseq: NM_029755
• UniProt ID: A2A6M5