Recombinant Mouse Bloc1s1 Protein, Myc/DDK-tagged

• Cat.No.: Bloc1s1-1872M
• Product Overview: Purified recombinant protein of mouse full-length biogenesis of lysosomal organelles complex-1, subunit 1 (Bloc1s1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 14.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 [ Mus musculus (house mouse) ]
• Official Symbol: Bloc1s1
• Synonyms: Bloc1s1; biogenesis of lysosomal organelles complex-1, subunit 1; BL; Gcn5; BLOS1; Gcn5l1; AI839753; biogenesis of lysosome-related organelles complex 1 subunit 1; BLOC-1 subunit 1; GCN5 general control of amino acid synthesis-like 1; GCN5-like protein 1; biogenesis of lysosome-related organelles complex-1, subunit 1; general control of amino acid synthesis, yeast homolog-like 1; general control of amino acid synthesis-like 1
• Gene ID: 14533
• mRNA Refseq: NM_015740
• Protein Refseq: NP_056555
• UniProt ID: O55102