Recombinant Mouse Bbs7 Protein, Myc/DDK-tagged

Cat.No. : Bbs7-1829M
Product Overview : Purified recombinant protein of mouse full-length Bardet-Biedl syndrome 7 (human) (Bbs7), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Species : Mouse
Source : HEK293
Tag : DDK&Myc
Description : The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
Molecular Mass : 80.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name Bbs7 Bardet-Biedl syndrome 7 (human) [ Mus musculus (house mouse) ]
Official Symbol Bbs7
Synonyms BBS7; Bardet-Biedl syndrome 7 (human); Bardet-Biedl syndrome 7 protein homolog; BBS2-like protein 1; 8430406N16Rik
Gene ID 71492
mRNA Refseq NM_027810
Protein Refseq NP_082086
UniProt ID Q8K2G4

Not For Human Consumption!

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