Recombinant Mouse Asxl1 Protein, Myc/DDK-tagged

• Cat.No.: Asxl1-1755M
• Product Overview: Purified recombinant protein of mouse full-length additional sex combs like 1 (Asxl1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Acts as a sensor of N6-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 163.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Asxl1 ASXL transcriptional regulator 1 [ Mus musculus (house mouse) ]
• Official Symbol: Asxl1
• Synonyms: ASXL1; additional sex combs like 1 (Drosophila); putative Polycomb group protein ASXL1; additional sex combs-like protein 1; mKIAA0978; DKFZp434N0535
• Gene ID: 228790
• mRNA Refseq: NM_001039939
• Protein Refseq: NP_001035028
• UniProt ID: P59598