ASXL1

  • Official Full Name

    additional sex combs like 1 (Drosophila)

  • Overview

    This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

  • Synonyms

    ASXL1;additional sex combs like 1 (Drosophila);putative Polycomb group protein ASXL1;KIAA0978;Additional sex combs like protein 1;OTTHUMP00000030592;OTTHUMP00000030593;OTTHUMP00000245206;additional sex combs-like protein 1;MDS;BOPS

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • In Vitro Cell Free System
  • HEK293T
  • HEK293
  • His
  • GST
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ASXL1-9951H Recombinant Human ASXL1, His-tagged E.coli Human His 1-84a.a.
ASXL1-2052M Recombinant Mouse ASXL1 Protein Mammalian Cell Mouse His
ASXL1-926H Recombinant Human ASXL1 protein, GST-tagged Wheat Germ Human GST
ASXL1-0414H Recombinant Human ASXL1 Protein (Lys1477-Arg1541), N-GST-tagged E.coli Human GST Lys1477-Arg1541
ASXL1-1409HF Recombinant Full Length Human ASXL1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 84 amino acids
Asxl1-1755M Recombinant Mouse Asxl1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
ASXL1-2926H Recombinant Human ASXL1 Protein, GST-tagged E.coli Human GST
ASXL1-2928H Recombinant Human ASXL1 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
ASXL1-805M Recombinant Mouse ASXL1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ASXL1-805M-B Recombinant Mouse ASXL1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ASXL1 involved in several pathways and played different roles in them. We selected most pathways ASXL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ASXL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    ASXL1 has several biochemical functions, for example, DNA binding,metal ion binding,peroxisome proliferator activated receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASXL1 itself. We selected most functions ASXL1 had, and list some proteins which have the same functions with ASXL1. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding SMYD2,CASZ1,COL1A1,Car14,MOXD2,ZNF789,DPYDB,TIMP2,RIOK2,EXT1
    protein binding CD2,SIK2,RPL4,OAS2,RPF1,DEFA6,MAGEC2,ARHGDIA,LARP7,KATNAL1
    transcription coactivator activity CALCOCO1,RUNX1,ZSCAN1,NCOA3,ABT1,PIAS1,RXRB,CCNE1,NR1I3,MYCBP
    DNA binding LIG4,TAF11,DMRT3,SOX15,NFE2L2A,NR1D2A,TOP3B,POLR1A,ZSCAN5A,HIST1H2B7
    peroxisome proliferator activated receptor binding PPARGC1A,NR0B2,HMGA1,IKBKG,NFATC4,EP300,PRMT2,HMGA1-RS1,ASXL2,MED1
    retinoic acid receptor binding PRMT2,AASS,PRAMEF6,ACTN4,CNOT1,LRIF1,PRAMEF2,RXRA,MED1,PRAME
    transcription corepressor activity ZHX3,HSBP1,BASP1,C1D,ZFPM1,CRYM,HDAC7,TLE2,DNMT3B,FOXP3

    Interacting Protein

    ASXL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASXL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASXL1.

    BAP1;EZH2;Bap1;ESR1;Rxra;THRB;AKT1

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