Recombinant Mouse Arhgef7 Protein, Myc/DDK-tagged

• Cat.No.: Arhgef7-1696M
• Product Overview: Purified recombinant protein of mouse full-length Rho guanine nucleotide exchange factor (GEF7) (Arhgef7), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
• Molecular Mass: 73.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Arhgef7 Rho guanine nucleotide exchange factor (GEF7) [ Mus musculus (house mouse) ]
• Official Symbol: Arhgef7
• Synonyms: ARHGEF7; Rho guanine nucleotide exchange factor (GEF7); rho guanine nucleotide exchange factor 7; beta-Pix; Pak3 binding protein; Pak interacting exchange factor; PAK-interacting exchange factor beta; PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142
• Gene ID: 54126
• mRNA Refseq: NM_017402
• Protein Refseq: NP_059098
• UniProt ID: Q9ES28