ARHGEF7
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 7 -
Overview
betaPix (ARHGEF7, Beta-Pix, COOL) is a Rho guanine nucleotide exchange factor (GEF). betaPix is a p21-activated protein kinase (PAK)-interacting exchange factor (Pix, COOL, p85SPR) that has been identified as a putative guanine nucleotide exchange factor (GEF) for Rac/Cdc42. The variants of betaPix isoforms exhibit different tissue distributions. betaPix-a is expressed ubiquitously in all the tissues examined, and other isoforms are expressed mainly in the central nervous system. PAK, a Ser/Thr kinase,Is an important mediator of Rho family activity interacts with betaPix at the SH3 domain of betaPix though its proline rich region. This interaction is thought to affect the GTP hydrolysis rate of Rac and Cdc42. -
Synonyms
ARHGEF7;Rho guanine nucleotide exchange factor (GEF) 7;rho guanine nucleotide exchange factor 7;BETA PIX;COOL1;DKFZp686C12170;DKFZp761K1021;guanine nucleotide exchange factor 7;KIAA0142;Nbla10314;P50;P50BP;P85;P85COOL1;P85SPR;PAK interacting exchange factor beta;PAK3;PIXB;rho;SH3 domain containing proline rich protein;PAK-interacting exchange factor beta;SH3 domain-containing proline-rich protein;COOL-1;BETA-PIX
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&T7
- His&Fc&Avi
Involved Pathway
ARHGEF7 involved in several pathways and played different roles in them. We selected most pathways ARHGEF7 participated on our site, such as Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | PIK3CB,RHOAB,ROCK2A,PDGFB,MAPK3,FGF2,HRAS,PTK2AA,PFN2L,VAV2 |
Protein Function
ARHGEF7 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF7 itself. We selected most functions ARHGEF7 had, and list some proteins which have the same functions with ARHGEF7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | CALM3,THY1,MVP,FOXO3,PARK2,SPDYE2,JIP1,PPME1,SPRED1,PXN |
| Rho guanyl-nucleotide exchange factor activity | TRIOA,MCF2L,ARHGEF16,ECT2,FGD4A,FGD2,VAV3,PLEKHG3,ARHGEF3,FGD1 |
| protein binding | ULK2,RNF2,ERO1LB,CD164,SMAD7,SIAH1A,MAGEA8,CDK5R1,HK2,POLB |
| guanyl-nucleotide exchange factor activity | DOCK4B,ARHGEF19,TRIO,DENND6A,ARHGEF3L,FGD2,FFAR1,VAV1,NET1,TBC1D10A |
Interacting Protein
ARHGEF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF7.
PAK1;SCRIB;LRRK2
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