Recombinant HumanFOSB,GST-tagged,113-151aa

• Cat.No.: FOSB-1303H

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Prouduct overview: Recombinant Human FOSB (a.a. 113-151) expressed inE.colishows a 32 kDa SDS-PAGE (Including GST). The FOS-B is purified by proprietary chromatographic techniques.
• Description: Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos- B include Fra-1 and Fra-2 genes. The 4 members of Fos gene family are: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins which can dimerize with proteins of the JUN family, thus forming the transcription factor complex AP-1. The FOS proteins act as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms exist for Fos B.
• Stability: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: FOSB FBJ murine osteosarcoma viral oncogene homolog B[ Homo sapiens ]
• Synonyms: FOSB; FBJ murine osteosarcoma viral oncogene homolog B; AP-1; G0S3; GOS3; GOSB; MGC42291; DKFZp686C0818; oncogene FOS-B; activator protein 1; activator protein 1; Protein fosB; G0/G1 switch regulatory protein 3
• Gene ID: 2354
• mRNA Refseq: NM_001114171
• Protein Refseq: NP_001107643
• MIM: 164772
• UniProt ID: P53539
• Chromosome Location: 19q13.3
• Function: protein dimerization activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding