Recombinant Human XRN1, GST-tagged

• Cat.No.: XRN1-101H
• Product Overview: Human XRN1 full-length ORF ( AAH48104.1, 1 a.a. - 459 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: GST
• Description: SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.
• Molecular Mass: 80.2 kDa
• AA Sequence: MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRII KPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMAKLHEHLKYF VNMKISTDKSWQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLR EEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHL HINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAG VAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSEY VFANAFILK
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: XRN1 5'-3' exoribonuclease 1 [ Homo sapiens (human) ]
• Official Symbol: XRN1
• Synonyms: XRN1; SEP1; 5'-3' exoribonuclease 1; strand-exchange protein 1 homolog
• Gene ID: 54464
• mRNA Refseq: NM_019001
• Protein Refseq: NP_061874
• MIM: 607994
• UniProt ID: Q8IZH2
• Chromosome Location: 3q23
• Pathway: Deadenylation-dependent mRNA decay; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1); Destabilization of mRNA by Tristetraprolin (TTP)
• Function: 5'-3' exonuclease activity; DNA binding; RNA binding; protein binding