Recombinant Human WWP2 Protein (A2-E870), His tagged

• Cat.No.: WWP2-0443H
• Product Overview: Recombinant Human 6His-TEV-(GG)-WWP2(A2-E870 end) Protein was expressed in E. coli.

Specification

• Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein length: A2-E870
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 80%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 5% glycerol, 1 mM DTT.
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: WWP2 WW domain containing E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]
• Official Symbol: WWP2
• Synonyms: WWP2; WW domain containing E3 ubiquitin protein ligase 2; NEDD4-like E3 ubiquitin-protein ligase WWP2; AIP2; WW domain-containing protein 2; atrophin-1 interacting protein 2; atrophin-1-interacting protein 2; Nedd-4-like ubiquitin-protein ligase; WWp2-like
• Gene ID: 11060
• mRNA Refseq: NM_007014
• Protein Refseq: NP_008945
• MIM: 602308
• UniProt ID: O00308