Recombinant Human WWP2, GST-tagged

• Cat.No.: WWP2-240H
• Product Overview: Recombinant full-length human WWP2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: WWP2 or WW domain containing E3 ubiquitin protein ligase 2 is a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. WWP2 contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. WWP2 is an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. WWP2 which is also called AIP2 can bind to atrophin-1.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tis-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~130 kDa
• Purity: >90% by densitometry
• Applications: Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: WWP2 WW domain containing E3 ubiquitin protein ligase 2 [ Homo sapiens ]
• Official Symbol: WWP2
• Synonyms: WWP2; WW domain containing E3 ubiquitin protein ligase 2; NEDD4-like E3 ubiquitin-protein ligase WWP2; AIP2; WW domain-containing protein 2; atrophin-1 interacting protein 2; atrophin-1-interacting protein 2; Nedd-4-like ubiquitin-protein ligase; WWp2-like
• Gene ID: 11060
• mRNA Refseq: NM_007014
• Protein Refseq: NP_008945
• MIM: 602308
• UniProt ID: O00308
• Chromosome Location: 16q22.1
• Pathway: Ubiquitin mediated proteolysis, organism-specific biosystem; Ubiquitin mediated proteolysis, conserved biosystem
• Function: RNA polymerase II transcription factor binding; RNA polymerase II transcription factor binding; acid-amino acid ligase activity; ligase activity; protein binding; transcription factor binding; ubiquitin-protein ligase activity; ubiquitin-protein ligase activity