WWP2
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Official Full Name
WW domain containing E3 ubiquitin protein ligase 2 -
Overview
This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
WWP2;WW domain containing E3 ubiquitin protein ligase 2;NEDD4-like E3 ubiquitin-protein ligase WWP2;AIP2;Atrophin 1 interacting protein 2;NEDD4 like E3 ubiquitin protein ligase;WW domain-containing protein 2;Wwp 2;atrophin-1 interacting protein 2;atrophin-1-interacting protein 2;Nedd-4-like ubiquitin-protein ligase;WWp2-like
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Insect Cell
- Sf9 Insect Cell
- Mammalian Cell
- Insect Cells
- HEK293T
- HEK293
- GST
- His
- His&GST
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
WWP2 involved in several pathways and played different roles in them. We selected most pathways WWP2 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | CDC34A,HERC4,UBE2M,UBE2N,UBE2D4,SKP1,SAE1,CDH1-A,TRIM32,TRAF6 |
Protein Function
WWP2 has several biochemical functions, for example, RNA polymerase II transcription factor binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WWP2 itself. We selected most functions WWP2 had, and list some proteins which have the same functions with WWP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | MARCH2,RNF115,FBXO3,RNF217,FBXO30A,TRAF3,FBXL14B,RCHY1,BRCA1,FBXO11 |
| transcriptional activator activity, RNA polymerase II transcription factor binding | NOTCH1,JUN,MED12,CLOCK,NFE2L1,PPARA,PITX1,NKX2-5,GBX2,MIXL1 |
| protein binding | CECR2,TFRC,PPP2R5E,P2RX7,APC,MKRN3,PTK2,GATA1,KRT83,MBIP |
| RNA polymerase II transcription factor binding | HCLS1,KDM1A,TBX6,ID4,PITX2,ZFPM2A,TOX2,MEF2A,SFPI1,XBP1 |
| transcription factor binding | FOXO4,EP300,REST,STK36,MYOD1,ATF7,HES3,LEF1,NR0B2A,TRIM11 |
| ligase activity | BRCA1,UBR5,PDZRN3,CNOT4,UBE2IA,NEURL1B,TRIM28,UBE2D1A,RNF31,PELI1 |
| ubiquitin protein ligase activity | UBE2KB,ARIH2,HECTD3,LRSAM1,HECW1,RNF144AA,DZIP3,HERC6,RNF180,UBE2NB |
Interacting Protein
WWP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WWP2.
WIPF1;HNRNPUL1;TRAF4;PDLIM7;SMAD3
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