Recombinant Human WWOX, His-tagged

• Cat.No.: WWOX-31530TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-234 of human WWOX fused to His tag at N-terminus; 254 amino acids, 28.3 kDa.

Specification

• Description: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG
• Sequence Similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family.Contains 2 WW domains.
• Protein length: 1-234 a.a.

Gene Information

• Gene Name: WWOX WW domain containing oxidoreductase [ Homo sapiens ]
• Official Symbol: WWOX
• Synonyms: WWOX; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; FOR; SDR41C1; short chain dehydrogenase/reductase family 41C; member 1; WOX1
• Gene ID: 51741
• mRNA Refseq: NM_016373
• Protein Refseq: NP_057457
• MIM: 605131
• Uniprot ID: Q9NZC7
• Chromosome Location: 16q23.3-q24.1
• Pathway: ErbB4 signaling events, organism-specific biosystem
• Function: coenzyme binding; cofactor binding; nucleotide binding; oxidoreductase activity; oxidoreductase activity