Recombinant Human WWOX, His-tagged

• Cat.No.: WWOX-525H
• Product Overview: Recombinant Human WWOX fused with His tag at N-terminus produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 254 amino acids (1-234 a.a.) and having a molecular mass of 28.3 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-234 a.a.
• Description: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism.
• Sequence: MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG.
• Purity: Greater than 85.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis bySDS-PAGE.
• Format: The WWOX solution (1mg/ml) contains 20mM Tris pH-8, & 10% glycerol.
• Storage: WWOX although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: WWOX WW domain containing oxidoreductase [ Homo sapiens ]
• Synonyms: WWOX; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; fragile site FRA16D oxidoreductase; short chain dehydrogenase/reductase family 41C, member 1; D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1
• Gene ID: 51741
• mRNA Refseq: NM_016373
• Protein Refseq: NP_057457
• MIM: 605131
• UniProt ID: Q9NZC7
• Chromosome Location: 16q23.3-q24
• Function: coenzyme binding; cofactor binding; oxidoreductase activity; protein binding; protein dimerization activity