Recombinant Human Vascular Endothelial Growth Factor B, His-tagged

• Cat.No.: VEGFB-128H
• Product Overview: Recombinant human VEGF-B protein was expressed in E.coli and purified by using conventional chromatography techniques, 21.6 kDa (207 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: VEGF-B, also known as Vascular endothelial growth factor-B, is one of 5 mammalian VEGF family members, the others being VEGF-A, VEGF-C, VEGF-D, and placental growth factor (PlGF). VEGF-B binds to one of the VEGF receptor tyrosine kinases, namely VEGF receptor-1(VEGFR1, Flt1), but not to VEGFR2 and VEGFR3. VEGF-B is homodimeric, heparin-binding glycoprotein involved in embryonic angiogenesis and vasculogenesis.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MPVSQPDAPG HQRKVVSWID VYTRATCQPR EVVVPLTVEL MGTVAKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ ILMIRYPSSQ LGEMSLEEHS QCECRPKKKD SAVKPDRAAT PHHRPQPRSV PGWDSAPGAP SPADITHPTP APGPSAHAAP STTSALTPGP AAAAADAAAS SVAKGGA
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 10% glycerol
• Purity: > 90% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: VEGFB vascular endothelial growth factor B [ Homo sapiens ]
• Synonyms: VEGF-B; VEGFL; VRF; VEGF-related factor; vascular endothelial growth factor B; VEGFB;VEGF-related factor (VRF)
• Gene ID: 7423
• mRNA Refseq: NM_003377
• Protein Refseq: NP_003368
• MIM: 601398
• UniProt ID: P49765
• Chromosome Location: 11q13
• Pathway: Cytokine-cytokine receptor interaction; Focal adhesion; Pancreatic cancer; Renal cell carcinoma; mTOR signaling pathway; Hemostasis; Signaling by VEGF
• Function: growth factor activity; heparin binding; protein binding; vascular endothelial growth factor receptor binding