Recombinant Human USP2 Protein, His-tagged

• Cat.No.: USP2-092H
• Product Overview: Recombinant C-terminally Histidine-tagged human USP2 enzyme (active catalytic domain, 259-605) was purified from E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 259-605
• Description: This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
• Molecular Mass: 40.9 kDa
• Purity: ≥95% as determined by SDS-PAGE
• Unit Definition: One unit is defined as the amount of USP2 enzyme required to produce 1 pmol of AMC per minute at room temperature in 50 mM HEPES, pH 7.8, 0.5 mM EDTA, 1 mM DTT, and 0.2% CHAPS.
• Stability: ≥ 2 years
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM HEPES, pH 8.0, 150 mM sodium chloride, 1 mM DTT, and 0.1 mM EDTA

Gene Information

• Gene Name: USP2 ubiquitin specific peptidase 2 [ Homo sapiens (human) ]
• Official Symbol: USP2
• Synonyms: USP2; ubiquitin specific peptidase 2; USP9; UBP41; ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; deubiquitinating enzyme 2; ubiquitin specific protease 12; ubiquitin specific protease 9; ubiquitin thioesterase 2; ubiquitin-specific-processing protease 2; EC 3.4.19.12
• Gene ID: 9099
• mRNA Refseq: NM_004205
• Protein Refseq: NP_004196
• MIM: 604725
• UniProt ID: O75604