Recombinant Human USP2 protein, GST-tagged

• Cat.No.: USP2-6843H
• Product Overview: Recombinant Human USP2 protein(259-410 aa), fused with N-terminal GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: N-GST
• Protein length: 259-410 aa
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization.
• AASequence: NSKSAQGLAGLRNLGNTCFMNSILQ CLSNTRELRDYCLQRLYMRDLHHGS NAHTALVEEFAKLIQTIWTSSPNDV VSPSEFKTQIQRYAPRFVGYNQQDA QEFLRFLLDGLHNEVNRVTLRPKSN PENLDHLPDDEKGRQMWRKYLERED SR
• Purity: 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, reconstitution with sterile water and addition of an equal volume of glycerol. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 μg/μl in 200 μl sterile water for short-term storage. After reconstitution with sterile water, if glycerol has no effect on subsequent experiments, it is recommended to add an equal volume of glycerol for long-term storage.

Gene Information

• Gene Name: USP2 ubiquitin specific peptidase 2 [ Homo sapiens ]
• Official Symbol: USP2
• Synonyms: USP2; ubiquitin specific peptidase 2; ubiquitin specific protease 2; ubiquitin carboxyl-terminal hydrolase 2; UBP41; ubiquitin thioesterase 2; deubiquitinating enzyme 2; ubiquitin specific protease 9; ubiquitin specific protease 12; 41 kDa ubiquitin-specific protease; ubiquitin-specific-processing protease 2; USP9
• Gene ID: 9099
• mRNA Refseq: NM_001243759
• Protein Refseq: NP_001230688
• MIM: 604725
• UniProt ID: O75604

Reviews

09/14/2022

Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.

03/09/2016

With the USP2 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.

02/03/2016

The USP2 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.

Q&As

Can USP2 serve as a biomarker for certain diseases?

It's possible. Elevated levels of USP2 have been associated with certain cancers and metabolic disorders, suggesting its potential as a biomarker for disease diagnosis and prognosis.

Are there any ongoing clinical trials targeting USP2 for diabetes treatment?

There's research interest in exploring USP2 inhibitors to potentially improve insulin sensitivity and manage diabetes, but clinical trials in this area are still in early stages.

Are there any clinical studies exploring the use of USP2 inhibitors in cancer treatment?

Yes, several studies are investigating USP2 inhibitors as potential therapeutic agents in cancer treatment to target specific pathways involved in tumor growth.

How does USP2 impact insulin sensitivity and diabetes?

USP2 has been shown to regulate insulin signaling by deubiquitinating proteins involved in insulin receptor signaling pathways. Dysregulation of USP2 may contribute to insulin resistance in diabetes.

Can USP2 be a potential therapeutic target for drug development?

Yes, due to its role in regulating protein stability, USP2 is being considered as a potential therapeutic target for drug development, especially in cancer and other diseases involving dysregulated protein turnover.