Recombinant Human UPF2 Protein, MYC/DDK-tagged

• Cat.No.: UPF2-632H
• Product Overview: Recombinant human UPF2 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008].
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 147.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: UPF2, regulator of nonsense mediated mRNA decay[ Homo sapiens ]
• Official Symbol: UPF2
• Synonyms: HUPF2; RENT2; smg-3
• Gene ID: 26019
• mRNA Refseq: NM_015542.3
• Protein Refseq: NP_056357.1
• MIM: 605529
• UniProt ID: Q9HAU5