UPF2
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Official Full Name
UPF2 regulator of nonsense transcripts homolog (yeast) -
Overview
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008] -
Synonyms
UPF2;UPF2 regulator of nonsense transcripts homolog (yeast);HUPF2;RENT2;smg-3;regulator of nonsense transcripts 2;yeast Upf2p homolog;nonsense mRNA reducing factor 2;up-frameshift suppressor 2 homolog;smg-3 homolog, nonsense mediated mRNA decay factor
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| UPF2-1875HFL | Recombinant Full Length Human UPF2 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| UPF2-2319H | Recombinant Human UPF2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| UPF2-2319H-B | Recombinant Human UPF2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| UPF2-632H | Recombinant Human UPF2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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Involved Pathway
UPF2 involved in several pathways and played different roles in them. We selected most pathways UPF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UPF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
UPF2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by UPF2 itself. We selected most functions UPF2 had, and list some proteins which have the same functions with UPF2. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
UPF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UPF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UPF2.
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References
- Geissler, V; Altmeyer, S; et al. The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. NUCLEIC ACIDS RESEARCH 41:7875-7888(2013).
- Ishigaki, Y; Li, XJ; et al. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. CELL 106:607-617(2001).
