Recombinant Human UBE2D2, His-tagged
Cat.No. : | UBE2D2-31647TH |
Product Overview : | Recombinant full length Human UBE2D2 with an N terminal His tag; 167 amino acids with tag, Predicted MWt 18.9 kDa. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 167 amino acids |
Description : | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. |
Conjugation : | HIS |
Molecular Weight : | 18.900kDa inclusive of tags |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0 |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM |
Sequence Similarities : | Belongs to the ubiquitin-conjugating enzyme family. |
Gene Name | UBE2D2 ubiquitin-conjugating enzyme E2D 2 [ Homo sapiens ] |
Official Symbol | UBE2D2 |
Synonyms | UBE2D2; ubiquitin-conjugating enzyme E2D 2; ubiquitin conjugating enzyme E2D 2 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 D2; UBC4; UbcH5B; |
Gene ID | 7322 |
mRNA Refseq | NM_003339 |
Protein Refseq | NP_003330 |
MIM | 602962 |
Uniprot ID | P62837 |
Chromosome Location | 5q31.3 |
Pathway | Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; |
Function | ATP binding; acid-amino acid ligase activity; ligase activity; nucleotide binding; protein binding; |
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Not For Human Consumption!
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