Recombinant Human TXNRD2, His-tagged

• Cat.No.: TXNRD2-31640TH
• Product Overview: Recombinant full length Human TXNRD2 with N terminal His tag

Specification

• Description: Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608
• Form: Lyophilised
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20mM HEPES, pH 7.4
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
• Full Length: Full L.

Gene Information

• Gene Name: TXNRD2 thioredoxin reductase 2 [ Homo sapiens ]
• Official Symbol: TXNRD2
• Synonyms: TXNRD2; thioredoxin reductase 2; thioredoxin reductase 2, mitochondrial; selenoprotein Z; thioredoxin reductase beta; TR; TR3; TRXR2
• Gene ID: 10587
• mRNA Refseq: NM_006440
• Protein Refseq: NP_006431
• MIM: 606448
• Uniprot ID: Q9NNW7
• Chromosome Location: 22q11.21
• Pathway: Oxidative Stress, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem; Pyrimidine metabolism, conserved biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem; Selenium Pathway, organism-specific biosystem
• Function: NADP binding; flavin adenine dinucleotide binding; oxidoreductase activity; protein binding; protein homodimerization activity