TXNRD2
-
Official Full Name
thioredoxin reductase 2 -
Overview
The reduced form of thioredoxin serves as a hydrogen donor, contributes to the up-regulation of various transcription factors and binds to and inhibits MAPKKK activity. Oxidized thioredoxin is converted back to the reduced form by Thioredoxin Reductase (TrxR2), a redox active enzyme. There are two distinct isoforms in mammalian cells, TrxR1, a cytosolic protein and TrxR2, almost exclusively a mitochondrial protein. TrxR expression is induced in several tumors. -
Synonyms
TXNRD2;thioredoxin reductase 2;thioredoxin reductase 2, mitochondrial;selenoprotein Z;thioredoxin reductase beta;TR;TR3;TRXR2;thioredoxin reductase 3;thioredoxin reductase TR3;SELZ;TR-BETA
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- SUMO
- Avi
- Fc
Involved Pathway
TXNRD2 involved in several pathways and played different roles in them. We selected most pathways TXNRD2 participated on our site, such as Cellular responses to stress,Detoxification of Reactive Oxygen Species,Oxidative Stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with TXNRD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular responses to stress | HSPA12B,CBX6,MAPKAPK2B,RAD50,Txn1,ERF,MINK1,WDR45,GABARAP,EEF1A1 |
| Selenium Metabolism and Selenoproteins | SELK,MSRB1,TXNRD3IT1,FBXO17,SELENBP1,TRNAU1AP,CREM,SP3,DIO2,SELT |
| Pyrimidine metabolism | ZNRD1,TXNRD3,PRIM1,NT5C1B,POLR1D,POLE,DUT,ENTPD4,POLD4,UCK2B |
| Detoxification of Reactive Oxygen Species | TXN,PRDX2,PRDX3,Txn1,TXN2 |
| Selenium | FMN1,MSRB1,SEPP1 |
| Oxidative Stress | JUNBA,TXN2,NQO1,NOX4,NFIX |
| Selenocompound metabolism | PSTK,INMT,MTR,CCBL1,PAPSS2A,SPS2,SEPSECS,PAPSS1,PAPSS2,MARS2 |
| Selenium Pathway | PRDX4,MSRB1,CRP,DIO2,SELT,SERPINA3,ALOX5AP,PRDX2,SAA4,SELK |
Protein Function
TXNRD2 has several biochemical functions, for example, flavin adenine dinucleotide binding,protein binding,thioredoxin-disulfide reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TXNRD2 itself. We selected most functions TXNRD2 had, and list some proteins which have the same functions with TXNRD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| flavin adenine dinucleotide binding | PPOX,CYB5R3,ACOX1,ACADM,KMO,DMGDH,ACAD9,FMO3,XDH,ACADSB |
| protein binding | RAET1D,ACTL6A,PSMA1,CCDC12,RAD9A,PYYA,MITF,CHDH,GSG2,VPS11 |
| thioredoxin-disulfide reductase activity | TXNRD1,NXN,TRR1,TXNRD3 |
Interacting Protein
TXNRD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TXNRD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TXNRD2.
NDUFA13
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