Recombinant Human Tumor Protein P73, GST-tagged

• Cat.No.: TP73-328H
• Product Overview: Full-length recombinant human TP73 alpha was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.

Specification

• Cat. No.: TP73-328H
• Description: TP73α is a member of the p53 family of transcription factors that are involved in cellular responses to stress and development. TP73 has high sequence similarity to p53 and p63, which allows p63 and TP73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. TP73 is a stress-response gene and a downstream effector in the p53 pathway. The TP73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. TP73 is the components of a mismatch repair-dependent apoptosis pathway which contributes to cisplatin-induced cytotoxicity.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 110 kDa
• Expression System: Sf9 insect cells using baculovirus
• Species: Human
• Form: Recombinant protein stored in 50mM Tris-HCI, pH 7.5, 150mM NaCl, 10 mMglutathione, 0.1 mMEDTA, 0.25 mM DTT, 0.1mM PMSF, 25% glycerol.
• Purity: >90%
• Concentration: 0.2ug/ul
• Sequences: Full-length
• Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Alpha6-Beta4 Integrin Signaling Pathway; Alpha6-Beta4 Integrin Signaling Pathway; Direct p53 effectors; E2F transcription factor network; Measles; Neurotrophin signaling pathway; TGF-beta Receptor Signaling Pathway; TP53 network; p53 signaling pathway

Gene Information

• Gene Name: TP73 tumor protein p73 [ Homo sapiens ]
• Official Symbol: TP73
• Synonyms: TP73; tumor protein p73;P73, OTTHUMP00000000662; OTTHUMP00000003477; OTTHUMP00000003478; OTTHUMP00000003479; OTTHUMP00000003480; p53-related protein; p53-like transcription factor
• Gene ID: 7161
• mRNA Refseq: NM_005427
• Protein Refseq: NP_005418
• MIM: 601990
• UniProt ID: O15350
• Chromosome Location: 1p36.3
• Function: Transcription repressor activity; Transcription factor binding; Transcription activator activity; Sequence-specific DNA binding transcription factor activity; Protein binding; promoter binding; p53 binding; Metal ion binding; Double-stranded DNA binding; Damaged DNA binding; Chromatin binding