TP73
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Official Full Name
tumor protein p73 -
Overview
The p73 gene has been mapped to the short arm of chromosome 1, position 1p36, a region frequently deleted in neuroblastomas. Allelic loss at 1p36 has also been reported in melanoma, breast carcinoma and colon carcinoma. The p73 transcript is differentially spliced to generate 2 mRNAs that code for the 2 isoforms of p73, p73alpha and p73beta. There is significant sequence homology between amino acid residues in the p73 isoforms and the DNA-binding, transactivation and oligomerization domains of p53. p73 activates p21WAF1 in transfected SK-N-AS cells and transfected SAOS2 cells, suggesting a role for p73 as a transcription factor. In similar transfection experiments, p73 was reported to induce apoptosis in SAOS2 and BHK cells. -
Synonyms
TP73;tumor protein p73;P73;p53-related protein;p53-like transcription factor
Recombinant Proteins
- Human
- Zebrafish
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- HEK293
- E.coli
- Non
- GST
- His
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TP73-30454TH | Recombinant Human TP73 | Sf9 Cells | Human | Non | 476 amino acids |
|
| TP73-30577TH | Recombinant Human TP73 | Insect Cells | Human | Non | 636 amino acids |
|
| TP73-30579TH | Recombinant Human TP73 | Sf9 Cells | Human | Non | 499 amino acids |
|
| TP73-328H | Recombinant Human Tumor Protein P73, GST-tagged | Sf9 Cells | Human | GST |
|
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| TP73-329H | Recombinant Human Tumor Protein P73, GST-tagged | Sf9 Cells | Human | GST |
|
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| TP73-330H | Recombinant Human Tumor Protein P73, GST-tagged | Sf9 Cells | Human | GST |
|
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| TP73-9700Z | Recombinant Zebrafish TP73 | Mammalian Cells | Zebrafish | His |
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| TP73-853HCL | Recombinant Human TP73 293 Cell Lysate | HEK293 | Human | Non |
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| TP73-2463H | Recombinant Human TP73 protein(261-350 aa), C-His-tagged | E.coli | Human | His | 261-350 aa |
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| TP73-4281H | Recombinant Human TP73 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| TP73-6327H | Recombinant Human TP73 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
TP73 involved in several pathways and played different roles in them. We selected most pathways TP73 participated on our site, such as p signaling pathway,Hippo signaling pathway,Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP73 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | TEAD4,FZD2,YWHAH,WNT3A,BMPR1A,CCND3,WNT7A,SMAD2,BMP4,APC |
| Neurotrophin signaling pathway | NGF,AKT2,MATK,CALM1,MAP2K2,PIK3CB,MAP2K5,KIDINS220,IRAK4,NTRK2 |
| Measles | IFNGR1,STAT2,TYK2,IFNGR2,IRF3,OAS2,TLR4,PIK3R2,NFKBIB,TLR2 |
| p signaling pathway | BIDA,CYCS,TRP53,STEAP3,GADD45BB,GTSE1,CCNG1,MDM2,SIAH2L,CASP9 |
Protein Function
TP73 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP73 itself. We selected most functions TP73 had, and list some proteins which have the same functions with TP73. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | HES1,LCOR,TFAP2A,TCF3,SIX2,HES6,RARA,ARHGEF2,DDIT3,NBN |
| protein kinase binding | PPP1R15A,HSPB1,ZFP36,PTPRC,TELO2,PPME1,SPDYA,NEFH,IBTK,SHC1 |
| protein binding | C2orf88,MICALL2,GLI1,DRD1A,PLN,PRKD3,SUPV3L1,RAB2A,NDUFA4,KIR2DL3 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZFP536,NEUROD1,Ar,TCF4,GZF1,NRF1,AGO1,MXD1,NDN,KLF16 |
| identical protein binding | GAPDH,PFKL,MSTN,GCC2,IGF2R,INS,IL12B,MYD88,EID3,DAPK3 |
| double-stranded DNA binding | SATB1,PRKDC,GATA1A,RAD51D,SMAD2,RAD51L1,NTHL1,TRP63,CGGBP1,LSM14A |
| damaged DNA binding | FEN1,GTF2H3,TP63,CREBBP,MPG,TRP53,RUVBL2,NEIL3,NEIL2,FANCG |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FEV,TFDP1B,SPI1B,TFAP2E,TWIST1,SPDEF,ZSCAN5A,MEF2D,ZNF446,PLAGX |
| metal ion binding | CYP39A1,SPON2,NENF,COX4I2,RXRBA,TIMP1,TRIM101,NT5DC1,NDUFS8,NME7 |
Interacting Protein
TP73 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP73 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP73.
HSPA9;AURKA
TP73 Related Signal Pathway
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References
- Santoni, M; Amantini, C; et al. Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells. BRITISH JOURNAL OF CANCER 109:1040-1050(2013).
- Casabonne, D; Reina, O; et al. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 96:323-327(2011).
