Recombinant Human Tumor Necrosis Factor (ligand) Superfamily, Member 11,His-tagged

• Cat.No.: TNFSF11-349H
• Product Overview: Recombinant human TNFSF11 protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography.

Specification

• Cat. No.: TNFSF11-349H
• Description: TNFSF11, also knownas RANKL, is a member of the tumor necrosis factor (TNF) cytokine familywhich is a ligand for osteoprotegerin and functions as a key factor forosteoclast differentiation and activation. TNFSF11 also has a function in theimmune system, where it is expressed by T helper cells and is thought to beinvolved in dendritic cell maturation. TNFSF11 is important in bonemetabolism. This natural and necessary surface-bound molecule (also known asCD254) found on osteoblasts serves to activate osteoclasts, which are thecells involved in bone resorption.
• Concentration: 0.5 mg/ml
• Source: Human
• Host: E.coli
• Form: Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCland 1mM DTT.
• Purity: > 80% by SDS -PAGE
• Sequence: 140-317 amino acids:MGSSHHHHHH SSGLVPRGSH MIRAEKAMVD GSWLDLAKRS KLEAQPFAHL TINATDIPSG SHKVSLSSWYHDRGWAKISN MTFSNGKLIV NQDGFYYLYA NICFRHHETS GDLATEYLQL MVYVTKTSIK IPSSHTLMKGGSTKYWSGNS EFHFYSINVG GFFKLRSGEE ISIEVSNPSL LDPDQDATYF GAFKVRDID
• Molecular Mass: 22.3 kDa(199aa), confirmed by MALDI-TOF.
• Applications: SDS-PAGE
• Storage: Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: TNFSF11
• Protein length: 140-317 a.a.

Gene Information

• Gene Name: TNFSF11tumor necrosis factor (ligand) superfamily, member 11 [ Homo sapiens ]
• Synonyms: TNFSF11; tumor necrosis factor (ligand) superfamily, member 11;ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; tumor necrosis factorligand superfamily member 11; OTTHUMP00000018328; OTTHUMP00000178585;osteoprotegerin ligand; osteoclast differentiation factor; TNF-relatedactivation-induced cytokine; receptor activator of nuclear factor kappa Bligand; receptor activator of nuclear factor kappa-B ligand
• Gene ID: 8600
• mRNA Refseq: NM_003701
• Protein Refseq: NP_003692
• MIM: 602642
• UniProt ID: O14788
• Chromosome Location: 13q14
• Pathway: Cytokine-cytokinereceptor interaction; IL6-mediated signaling events; Osteoblast Signaling;Osteoclast differentiation; Rheumatoid arthritis
• Function: cytokineactivity; receptor activity; tumor necrosis factor receptor binding; tumornecrosis factor receptor superfamily binding